Chasteberry Tree? The effects of essential fatty acid supplementation by Efamol in hyperactive children. View abstract. The effect of gamma-linolenic acid on clinical status, red cell fatty acid composition and membrane microviscosity in infants with atopic dermatitis. Poisson J, Germain-Bellenger S, Engler M, and et al. View abstract. 2017 Mar 25;9(4). van der Merwe CF, Booyens J, Joubert HF, van der Merwe CA. A prospective, double-blind, placebo-controlled multicentre clinical trial. Rev.Esc Enferm.USP. Purewal TS, Evans PMS, Havard F, O'Hare JP. 6-15-1989;129(5):381-388. View abstract. View abstract. If you experience breast pain so severe during your period that it … Down the primrose path: petechiae in a neonate exposed to herbal remedy for parturition. North American Menopause Society. Whitaker DK, Cilliers J, de Beer C. Evening primrose oil (Epogam) in the treatment of chronic hand dermatitis: disappointing therapeutic results. Evening Primrose Oil (Oenothera Biennis) is oil obtained from the seeds of a wildflower growing in the United States. Yoon, S., Lee, J., and Lee, S. The therapeutic effect of evening primrose oil in atopic dermatitis patients with dry scaly skin lesions is associated with the normalization of serum gamma-interferon levels. Black cohosh root? 43 years experience Pathology. Uccella, R., Contini, A., and Sartorio, M. [Action of evening primrose oil on cardiovascular risk factors in insulin-dependent diabetics]. Johnson, S. R. Premenstrual syndrome therapy. View abstract. Goyal, A. and Mansel, R. E. A randomized multicenter study of gamolenic acid (Efamast) with and without antioxidant vitamins and minerals in the management of mastalgia. Vitamin E and evening primrose oil for management of cyclical mastalgia: a randomized pilot study. Ring, J. and Kleinheinz, A. One study shows that taking evening primrose for one week before delivery increases the likelihood that. Smith, R. L., Pruthi, S., and Fitzpatrick, L. A. Horrobin, D. F. Lipids and schizophrenia. View abstract. Tanzan Health Res Bull 2007;9(3):196-201. Effects of altering dietary essential fatty acids on requirements for non-steroidal anti-inflammatory drugs in patients with rheumatoid arthritis: A double blind placebo controlled study. Placebo-controlled trial of essential fatty acid supplementation in atopic dermatitis. Rezapour-Firouzi S, Arefhosseini SR, Mehdi F, et al. 2020;27(12):4844-4852. Centre for Reviews and Dissemination. J Dev Behav Pediatr 2007;28:82-91. Most women use either over-the-counter (OTC) pain relievers or home remedies. Scand.J Rheumatol.Suppl 1986;61:242-245. Lis-Balchin, M. Parallel placebo-controlled clinical study of a mixture of herbs sold as a remedy for cellulite. 2009;19(1):43-46. The effect of dietary supplementation with evening primrose oil of hyperkinetic children. Phytother Res 2012;26:265-272. One early study shows that taking 6 grams daily for16 weeks improves scores on a psychological rating scale. 1. Evening primrose oil and atopic eczema. Clin Exp Dermatol. A double-blind trial of essential fatty acid supplementation in patients with tardive dyskinesia. Newman, V., Rock, C. L., Faerber, S., Flatt, S. W., Wright, F. A., and Pierce, J. P. Dietary supplement use by women at risk for breast cancer recurrence. Drugs Exp Clin Res 1988;14(4):285-290. Cochrane Database.Syst.Rev. View abstract. Evening primrose oil (Efamol) in the treatment of Raynaud's phenomenon: a double blind study. Muggli, R. Natural management of napkin rash. Womens Health Issues 1994;4(3):130-137. Gynecol.Endocrinol. Shaw D, Leon C, Kolev S, Murray V. Traditional remedies and food supplements: a 5-year toxicological study (1991-1995). Ann.Pharmacother. Complement Ther Med 2013;21(5):473-80. View abstract. Gibson RA. Part 2: Rheumatoid arthritis. Stenius-Aarniala B, Aro A, Hakulinen A, Ahola I, Seppala E, and Vapaatalo H. Evening primrose oil and fish oil are ineffective as supplementary treatment of bronchial asthma. Casper RF and Powell AM. 1990;1(4):199-201. According to the NIH, this home remedy is likely safe when used for short periods. View abstract. Effect of oral gamolenic acid from evening primrose oil on menopausal flushing (abstract). Schizophr.Res 4-10-1998;30(3):193-208. J Abnorm Child Psychol 1987;15:75-90. Hunter JO and Wilson AJ. Engler MM. 2012;3, Centre for Reviews and Dissemination. 2002;79(3):195-207. 1993;27(12):1475-1477. Asthma. Tong M. [Treatment of hyperlipemia with evening primrose oil capsules]. Bassey EJ, Littlewood JJ, Rothwell MC, and Pye DW. 1994;4(598):603. Cortisone in ulcerative colitis. Haslett C, Douglas JG, Chalmers SR, Weighhill A, and Munro JF. Negative effects from taking evening primrose oil for weight loss are mild digestive issues and headaches. Effect of primrose oil on serum lipids and blood pressure in hyperlipidemic subjects. View abstract. Jantti J, Seppala E, Vapaatalo H, and Isomaki H. Evening primrose oil and olive oil in treatment of rheumatoid arthritis. Early research shows that taking a specific evening primrose product 3 grams daily for 6 months improves dry eye symptoms in women wearing soft contact lenses. Makrides M, Neumann M, Simmer K, Pater J, and Gibson R. Are long-chain polyunsaturated fatty acids essential nutrients in infancy? Am J Psychiatry 1986;143(7):912-914. View abstract. Evening primrose oil might interact with medications used during surgery. . EPO may contribute to pregnancy complications and increased bleeding in people taking warfarin and other blood-thinning drugs. In another clinical trial, EPO had no effect on PMS symptoms. In fact, its side effects may outweigh any potential benefits. Int J Cancer 2004;10;109:949-54. Berth-Jones, J., Thompson, J., and Graham-Brown, R. A. According to the Natural Standard Research Collaboration, allergy or hypersensitivity to oral evening primrose oil is uncommon but it may cause contact dermatitis [ 4 ]. Unfortunately, science does not support these claims. Most studies regarding its role in the treatment of PMS, menopause symptoms, digestive disorders, eczema or cancer have conflicting results, according to the Memorial Sloan Kettering Cancer Center (MSKCC). Phytother Res. Diabet Med 1994;11:145-9. Huntley, A. L. and Ernst, E. A systematic review of herbal medicinal products for the treatment of menopausal symptoms. Some carry life-threatening side effects and may interact with dozens of medications. View abstract. View abstract. Prevalence and treatment. Effect of exercise on FA profiles in n-3 FA-supplemented and -nonsupplemented premenopausal women. . Inflamm.Bowel.Dis 2002;8(3):174-179. One person who was taking evening primrose oil and other medications had a seizure during surgery. View abstract. Ty-Torredes KA. Drugs Exp Clin Res 1988;14:291-7. Evening primrose oil contains GLA (gamma-linolenic acid). The 10 Most Annoying Women's Health Issues and How to Fix Them, selective serotonin reuptake inhibitors (SSRIs), 8 Warning Signs of Depression You Shouldn't Ignore, U.S. Department of Health & Human Services: "Premenstrual Syndrome (PMS)", Mayo Clinic: "Daily Aspirin Therapy: Understand the Benefits and Risks", FDA: "Dietary Supplement Products & Ingredients", Pharmacological Reviews: "Botanicals and Their Bioactive Phytochemicals for Women’s Health", Advances in Pharmacological Sciences: "Review of Anti-Inflammatory Herbal Medicines", Cochrane: "Oral Evening Primrose Oil and Borage Oil for Eczema", Mount Sinai: "Evening Primrose Oil (EPO)", Mayo Clinic: "Selective Serotonin Reuptake Inhibitors (SSRIs)", Pharmacy Today: "Review Uncovers Dangerous Herb–Drug Interactions", PARTNER & LICENSEE OF THE LIVESTRONG FOUNDATION. Dermatology 1996;193:115-20. Topical evening primrose oil as a possible therapeutic alternative in children with molluscum contagiosum. 8-8-2005;226(1):17-25. Int.J Clin Pharmacol Ther. View abstract. Evening primrose oil for menopause is absolutely safe for the majority of people. Among them: 1. Bayles, B. and Usatine, R. Evening primrose oil. View abstract. Rock, E. and DeMichele, A. Nutritional approaches to late toxicities of adjuvant chemotherapy in breast cancer survivors. Clin Obstet.Gynecol. 2005;3(1):7-10. View abstract. Am J Obstet Gynecol. Evening primrose oil and fish oil for severe chronic mastalgia: a randomized, double-blind, controlled trial. Laugharne, J. D., Mellor, J. E., and Peet, M. Fatty acids and schizophrenia. Psychiatry Res 1989;27(3):313-323. View abstract. Conquer, J. J Pediatr 2008;152:140, 140.e1. View abstract. J Physiol Pharmacol 2010;61(5):637-643. New York: Wiley-Liss;1990. Cheung KL. View abstract. 1998;98(3):285-292. Klinische, immun- und lipidmodulatorische effekte einer behandlung mit ungesattigten fettsauren bei atopischer dermatitis. Clinical Uses of Essential Fatty Acids. Aragona, P., Bucolo, C., Spinella, R., Giuffrida, S., and Ferreri, G. Systemic omega-6 essential fatty acid treatment and pge1 tear content in Sjogren's syndrome patients. Ann Rheum.Dis 1989;48(11):965-966. Infant development. View abstract. Leaf Group Ltd. A pregnancy complication marked by high blood pressure and protein in the urine (pre-eclampsia). An integrative medicine approach to premenstrual syndrome. 1990;77(10):1110-1112. Prostaglandins Leukot.Essent.Fatty Acids 1999;60(3):199-208. Mayo Clin Proc. Evening primrose oil and magnesium have been shown to be effective. Br J Dermatol 1987;117:11-9. Chenoy R, Hussain S, Tayob Y, et al. Balci FL, Uras C, Feldman S. Clinical factors affecting the therapeutic efficacy of evening primrose oil on mastalgia. A motor skill disorder marked by clumsiness (developmental coordination disorder or DCD). View abstract. Taking up to 4 … Horrobin, D. F. The role of essential fatty acids and prostaglandins in the premenstrual syndrome. Can Fam.Physician 2002;48:1789-1797. Darsareh, F., Taavoni, S., Joolaee, S., and Haghani, H. Effect of aromatherapy massage on menopausal symptoms: a randomized placebo-controlled clinical trial. Early research in children shows that applying evening primrose oil to water warts on the skin for 3 months might cause the lesions to disappear faster than doing nothing at all. Clin Exp Hypertens B 1983;2:247-54. Int J Cancer 2000;85:643-8. View abstract. ), allergies, pre-existing diseases, and current health conditions (e.g. The problem is that it may interact with certain drugs, including anticoagulants, antidepressants and antihypertensives. Liu, H. and Zhou, J. F. [Xianbai buyang Huanwu decoction used for treating hypertension with kidney qi deficiency and blood stasis]. J Fam.Pract. An alternative is to use home remedies like ginger, evening primrose oil (EPO) or ginkgo biloba. Cochrane Database Sys Rev 2012;(1):CD009560. 2001;44(4):853-863. Skin Pharmacol Appl.Skin Physiol 2002;15(1):20-25. The effect of evening primrose oil supplementation on serum fatty acid and plasma prostaglandin levels. Invest Ophthalmol.Vis.Sci 2005;46(12):4474-4479. Women Health 1992;19:117-31. The effect of oral evening primrose oil on bishop score and cervical length amongst term gravidas. Little is known about the actual benefits of evening primrose oil. Qureshi, S. and Sultan, N. Topical nonsteroidal anti-inflammatory drugs versus oil of evening primrose in the treatment of mastalgia. To be on the safe side, you should stop taking evening primrose oil at least 2 weeks before surgery. Neurol.Res 2008;30(7):710-719. Phytother.Res 2009;23(12):1647-1662. 2020;27(2):194-198. 2006;195(6 Suppl 1):S30. View abstract. Several small studies show that taking 15-20 mL or 4-6 grams of evening primrose daily for up to 16 weeks doesn't improve asthma symptoms. Meigel, W., Dettke, T., Meigel, E. M., and Lenze, U. Hederos CA, Berg A. Epogam evening primrose oil treatment in atopic dermatitis and asthma. Journal of Dermatological Treatment 1993;4:33-36. A controlled trial of evening primrose oil (Efamol) in cyclic premenstrual mastalgia. But taking evening primrose oil doesn't seem to improve finger temperature or spasm of the blood vessels caused by cold. Pellegrina, C. D., Padovani, G., Mainente, F., Zoccatelli, G., Bissoli, G., Mosconi, S., Veneri, G., Peruffo, A., Andrighetto, G., Rizzi, C., and Chignola, R. Anti-tumour potential of a gallic acid-containing phenolic fraction from Oenothera biennis. Taking evening primrose, up to 4 grams daily for 4-6 weeks, doesn't seem to improve ADHD symptoms in children. It's also marketed for its ability to relieve the pain and discomfort associated with arthritic disorders, eczema, liver cancer and other ailments. 1992;79(5):407-409. 2005;54(9):789-800. Biagi PL, Bordoni A, Hrelia S, et al. Lets take a look at other precautions to be mindful of when using evening primrose oil. Z.Hautkr. Sharpe, G. R. and Farr, P. M. Evening primrose oil and eczema. Wong, V. C., Lim, C. E., Luo, X., and Wong, W. S. Current alternative and complementary therapies used in menopause. View abstract. Am J Obstet Gynecol 2002;187:1389-94.. View abstract. A double-blind evaluation of evening primrose oil as an antiobesity agent. Evening primrose oil or other omega-6 fatty acids should be avoided by anyone who suffers a seizure disorder or bleeding problems. View abstract. View abstract. Parveen, S. Sarwar G. Ali M. Channa G. A. Danazol versus oil of evening primrose in the treatment of mastalgia. View abstract. But this combination might reduce the rate of swelling (edema). Medications used during surgery (Anesthesia) interacts with EVENING PRIMROSE OIL. Engler MM, Engler MB, Erickson SK, Paul SM. View abstract. Evening Primrose Oil Side Effects: This oil uses in several major diseases like eczema, psoriasis, multiple syndrome, heart disease, dyspraxia etc. The risks are even greater for pregnant women who use this remedy to reduce labor time. Gateley, C. A., Miers, M., Mansel, R. E., and Hughes, L. E. Drug treatments for mastalgia: 17 years experience in the Cardiff Mastalgia Clinic. View abstract. ACP J Club. Some phenothiazines include chlorpromazine (Thorazine), fluphenazine (Prolixin), trifluoperazine (Stelazine), thioridazine (Mellaril), and others. Lancet 1-31-1981;1(8214):278. View abstract. View abstract. View abstract. Dove D, Johnson P. Oral evening primrose oil: its effect on length of pregnancy and selected intrapartum outcomes in low-risk nulliparous women (abstract). O'Brien PM, Pipkin FB. Humphreys F, Symons J, Brown H, and et al. Effects of safflower oil and evening primrose oil in men with a low dihomo-gamma-linolenic level. J Br Menopause.Soc 2004;10(4):162-165. Consult your doctor before taking this supplement, especially if you're under medical treatment or preparing for surgery. View abstract. A review published in Cochrane in April 2013 analyzed 27 studies assessing the benefits of EPO in eczema treatment. View abstract. Lack of effect of evening primrose oil on autonomic function tests after 12 months of treatment. Swed J Biol Med 1986;4:8-11. J.Atten.Disord. View abstract. Budeiri D, Li Wan Po A, Dornan JC. Cornea 2003;22(2):97-101. Therefore, always take evening primrose oil with food to avoid upset stomachs and other gastrointestinal side-effects. View abstract. Menendez JA, del Mar Barbacid M, Montero S, et al. In one study, infants fed this formula had better eyesight than infants fed regular formula, but not better than those who were breastfed. View abstract. Puri BK. Dark adaptation, motor skills, docosahexaenoic acid, and dyslexia. Evening primrose oil side effects may include headaches, nausea, stomach pain and digestive distress as well as more serious issues, such as lipoid pneumonia. View abstract. The potential for dietary supplements to reduce premenstrual syndrome (PMS) symptoms. Gehring W, Bopp R, Rippke F, and Gloor M. Effect of topically applied evening primrose oil on epidermal barrier function in atopic dermatitis as a function of vehicle. J Obstet Gynaecol 2006;26(4):344-347. vitamins, herbal supplements, etc. View abstract. Menopause. View abstract. Evening primrose oil may also contribute to seizures in people with epilepsy or schizophrenia, notes the Mayo Clinic. View abstract. Cochrane Database Sys Rev 2010 2010;11:CD001123. View abstract. Journal of Reproductive and Infant Psychology 2006;24(4):363-378. In fact, serotonin is often referred to as the "happy" or "feel-good" hormone. 2010;50(5):e106-e115. Evening Primrose Oil Side Effects. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. Br Med J 1955;11:1041-1048. Khorshidi M, Zarezadeh M, Moradi Moghaddam O, et al. Aging (Milano.) View abstract. Barber A. Effects of evening primrose oil in the treatment of premenstrual syndrome. Where did you or where do you plan to purchase this product? Kemmerich, B. Taylor, M. Botanicals: medicines and menopause. G.Clin Med 1987;68(1):23-28. Huntley, A. Drug-herb interactions with herbal medicines for menopause. Williams HC. View abstract. Essential fatty acid supplementation in tardive dyskinesia. Ferrando, J. J Am Diet Assoc 2000;100:1368-80. Prog Lipid Res 1992;31(2):163-194. Holman CP and Bell AF. Papas, E. Mcoptom D. Dry Eye and Diet: What Research Says About Essential Fatty Acids. J Clin Immunol 2002;22:83-91. 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